| Item Type | Name |
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Concept
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Cyclic AMP
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Concept
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Benzocaine
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Concept
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Cats
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Concept
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Base Sequence
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Concept
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Cations, Divalent
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Concept
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Biotin
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Concept
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Cell Separation
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Concept
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Genes, Synthetic
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Concept
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Golgi Apparatus
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Concept
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Guinea Pigs
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Concept
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Cysteine
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Concept
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Dogs
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Concept
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Cyclopentanes
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Concept
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Isoproterenol
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Concept
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Electrophysiology
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Concept
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Ethyl Methanesulfonate
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Concept
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Manganese
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Concept
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Drosophila melanogaster
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Concept
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Colforsin
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Concept
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Electric Conductivity
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Concept
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Hydrogen-Ion Concentration
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Concept
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Insecticides
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Concept
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Hydrolysis
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Concept
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Models, Cardiovascular
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Concept
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Markov Chains
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Concept
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Monte Carlo Method
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Concept
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Mutation
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Concept
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Myocardial Contraction
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Concept
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Isoleucine
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Concept
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Oocytes
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Concept
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Mesylates
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Concept
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Microscopy, Electron
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Concept
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Phenothiazines
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Concept
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Oxazoles
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Concept
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Protein Synthesis Inhibitors
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Concept
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Forecasting
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Concept
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Rabbits
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Concept
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Sea Anemones
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Concept
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Humans
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Concept
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Genetic Variation
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Concept
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Sodium Channels
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Concept
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Glutamic Acid
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Concept
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Reverse Transcriptase Polymerase Chain Reaction
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Concept
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Moricizine
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Concept
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Exercise
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Concept
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Porosity
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Concept
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Rats, Sprague-Dawley
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Concept
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Mutagenesis, Site-Directed
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Concept
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Alternative Splicing
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Concept
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Point Mutation
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Concept
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Sequence Deletion
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Concept
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Gene Expression Regulation, Developmental
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Concept
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DNA, Complementary
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Concept
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Sodium Channel Blockers
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Concept
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Casein Kinase Idelta
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Concept
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Amino Acid Substitution
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Concept
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Mice
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Concept
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Rats, Inbred Strains
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Concept
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Sarcoplasmic Reticulum
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Concept
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Rats
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Concept
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Static Electricity
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Concept
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Sucrose
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Concept
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Temperature
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Concept
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Cardiac Electrophysiology
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Concept
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Open Reading Frames
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Concept
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Transfection
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Concept
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Blotting, Northern
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Concept
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Polymerase Chain Reaction
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Concept
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Cations
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Concept
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Chymotrypsin
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Concept
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Cloning, Molecular
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Concept
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Diastole
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Concept
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Electrochemistry
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Concept
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Epilepsy, Generalized
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Concept
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Fluorescent Dyes
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Concept
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Kinetics
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Concept
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Lanthanum
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Concept
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Protons
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Concept
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Recombinant Fusion Proteins
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Concept
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Systole
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Concept
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Potassium Channels, Voltage-Gated
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Academic Article
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Leucine 18, a hydrophobic residue essential for high affinity binding of anthopleurin B to the voltage-sensitive sodium channel.
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Academic Article
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Mechanism of cAMP-dependent modulation of cardiac sodium channel current kinetics.
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Academic Article
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The role of exposed tryptophan residues in the activity of the cardiotonic polypeptide anthopleurin B.
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Academic Article
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Structure and function of voltage-dependent sodium channels: comparison of brain II and cardiac isoforms.
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Academic Article
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Optimization of a mammalian expression system for the measurement of sodium channel gating currents.
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Academic Article
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Nonequilibrium response spectroscopy of voltage-sensitive ion channel gating.
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Academic Article
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Role for Pro-13 in directing high-affinity binding of anthopleurin B to the voltage-sensitive sodium channel.
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Academic Article
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A specific interaction between the cardiac sodium channel and site-3 toxin anthopleurin B.
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Academic Article
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Cardiac sodium channels expressed in a peripheral neurotumor-derived cell line, RT4-B8.
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Academic Article
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Modification of inactivation in cardiac sodium channels: ionic current studies with Anthopleurin-A toxin.
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Academic Article
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Voltage-dependent open-state inactivation of cardiac sodium channels: gating current studies with Anthopleurin-A toxin.
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Academic Article
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Augmentation of recovery from inactivation by site-3 Na channel toxins. A single-channel and whole-cell study of persistent currents.
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Academic Article
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Differences in the binding sites of two site-3 sodium channel toxins.
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Academic Article
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The Na channel voltage sensor associated with inactivation is localized to the external charged residues of domain IV, S4.
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Academic Article
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Mibefradil block of cloned T-type calcium channels.
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Academic Article
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Gating of skeletal and cardiac muscle sodium channels in mammalian cells.
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Academic Article
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The role of the putative inactivation lid in sodium channel gating current immobilization.
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Academic Article
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Point mutations in domain III of a Drosophila neuronal Na channel confer resistance to allethrin.
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Academic Article
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Heartthrobs.
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Academic Article
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Lidocaine alters activation gating of cardiac Na channels.
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Academic Article
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Two components of use-dependent block of sodium current by lidocaine in voltage clamped cardiac Purkinje cells.
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Academic Article
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Atrionatriuretic peptide and calcium-conducting sodium channels.
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Academic Article
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Arg-14 loop of site 3 anemone toxins: effects of glycine replacement on toxin affinity.
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Academic Article
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Role of Asn-16 and Ser-19 in anthopleurin B binding. Implications for the electrostatic nature of Na(V) site 3.
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Academic Article
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Charge immobilization of the voltage sensor in domain IV is independent of sodium current inactivation.
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Academic Article
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Accessibility of mid-segment domain IV S6 residues of the voltage-gated Na+ channel to methanethiosulfonate reagents.
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Academic Article
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Molecular action of lidocaine on the voltage sensors of sodium channels.
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Academic Article
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State-dependent mibefradil block of Na+ channels.
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Academic Article
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Kinetic analysis of single sodium channels from canine cardiac Purkinje cells.
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Academic Article
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Gating currents associated with Na channels in canine cardiac Purkinje cells.
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Academic Article
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Charge at the lidocaine binding site residue Phe-1759 affects permeation in human cardiac voltage-gated sodium channels.
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Academic Article
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Outward stabilization of the S4 segments in domains III and IV enhances lidocaine block of sodium channels.
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Academic Article
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Sodium channels in cardiac Purkinje cells.
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Academic Article
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Role of Domain IV/S4 outermost arginines in gating of T-type calcium channels.
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Academic Article
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State-dependent verapamil block of the cloned human Ca(v)3.1 T-type Ca(2+) channel.
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Academic Article
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Isoform-dependent interaction of voltage-gated sodium channels with protons.
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Academic Article
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Open sodium channel properties of single canine cardiac Purkinje cells.
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Academic Article
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Site-3 toxins and cardiac sodium channels.
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Academic Article
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The N terminus of connexin37 contains an alpha-helix that is required for channel function.
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Academic Article
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Profiling the array of Ca(v)3.1 variants from the human T-type calcium channel gene CACNA1G: alternative structures, developmental expression, and biophysical variations.
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Academic Article
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An inner pore residue (Asn406) in the Nav1.5 channel controls slow inactivation and enhances mibefradil block to T-type Ca2+ channel levels.
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Academic Article
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Is there a second external lidocaine binding site on mammalian cardiac cells?
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Academic Article
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Use-dependent block of sodium current by ethmozin in voltage-clamped internally perfused canine cardiac Purkinje cells.
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Academic Article
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Lidocaine partially depolarizes the S4 segment in domain IV of the sodium channel.
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Academic Article
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The sodium channel as a target for local anesthetic drugs.
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Academic Article
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Using lidocaine and benzocaine to link sodium channel molecular conformations to state-dependent antiarrhythmic drug affinity.
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Academic Article
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Nonlinear relation between Vmax and INa in canine cardiac Purkinje cells.
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Academic Article
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The Anrep effect: an intrinsic myocardial mechanism.
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Academic Article
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Sodium channel molecular conformations and antiarrhythmic drug affinity.
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Academic Article
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A direct effect of forskolin on sodium channel bursting.
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Academic Article
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Effects of inotropic interventions on end systolic length-force curve of cat ventricular muscle.
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Academic Article
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Sodium current in voltage clamped internally perfused canine cardiac Purkinje cells.
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|
Academic Article
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Mechanisms of extracellular divalent and trivalent cation block of the sodium current in canine cardiac Purkinje cells.
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Academic Article
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Multiple cationic residues of anthopleurin B that determine high affinity and channel isoform discrimination.
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Academic Article
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Time-dependent changes in kinetics of Na+ current in single canine cardiac Purkinje cells.
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Academic Article
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Modification of sodium channel inactivation by alpha-chymotrypsin in canine cardiac Purkinje cells.
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Academic Article
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Evidence for multiple effects of ProTxII on activation gating in Na(V)1.5.
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Academic Article
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A structural motif for the voltage-gated potassium channel pore.
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Academic Article
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Extracellular divalent and trivalent cation effects on sodium current kinetics in single canine cardiac Purkinje cells.
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Academic Article
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Dose-dependent modulation of the cardiac sodium channel by sea anemone toxin ATXII.
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Academic Article
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Inhibition of the activation pathway of the T-type calcium channel Ca(V)3.1 by ProTxII.
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Academic Article
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Kinetic effects of quaternary lidocaine block of cardiac sodium channels: a gating current study.
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Academic Article
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The outermost lysine in the S4 of domain III contributes little to the gating charge in sodium channels.
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Academic Article
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Polyvalent cations constitute the voltage gating particle in human connexin37 hemichannels.
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Academic Article
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Endocytosis and uptake of lucifer yellow by cultured atrial myocytes and isolated intact atria from adult rats. Regulation and subcellular localization.
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Academic Article
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Outward stabilization of the voltage sensor in domain II but not domain I speeds inactivation of voltage-gated sodium channels.
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Academic Article
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Important Role of Asparagines in Coupling the Pore and Votage-Sensor Domain in Voltage-Gated Sodium Channels.
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|
Concept
|
NAV1.2 Voltage-Gated Sodium Channel
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Concept
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NAV1.5 Voltage-Gated Sodium Channel
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Concept
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Voltage-Gated Sodium Channel beta-3 Subunit
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Concept
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NAV1.3 Voltage-Gated Sodium Channel
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Grant
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Cardiac Channels: Targets of Drugs that Affect Kinetics
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|
Grant
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STRUCTURAL BASES OF T-TYPE CALCIUM CHANNEL FUNCTION
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Grant
|
Structure-Function of the Cardiac Sodium Channel
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Grant
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Drug therapy targeted to the voltage-gated sodium channel
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